What role does genetics play in toxicological responses?
Genetics is a fundamental factor in toxicology as it determines how individuals metabolize and respond to chemicals. Genetic polymorphisms can lead to variations in enzyme activity, which in turn affects the conversion of chemicals into active or inactive forms. For instance, differences in the cytochrome P450 enzyme system can result in either heightened sensitivity or resistance to certain drugs or toxins. Understanding these genetic differences is essential for assessing toxicity risk and developing personalized medicine approaches.
