Death receptors are critical in toxicology because they help determine how cells respond to toxic substances. Understanding the pathways activated by these receptors can aid in elucidating mechanisms of toxicity, predicting toxicological outcomes, and designing therapeutic interventions. For instance, some toxicants are known to activate death receptors, leading to tissue damage and organ failure. Conversely, resistance to death receptor-mediated apoptosis can lead to cancer development and treatment resistance.
