Yes, nucleotide analogues can be toxic. These compounds are structurally similar to natural nucleotides and can be incorporated into nucleic acids during replication or transcription. This incorporation can lead to chain termination, mutations, or other disruptions in nucleic acid function. Certain nucleotide analogues are used as antiviral drugs or anticancer agents due to their ability to inhibit viral replication or cancer cell proliferation. However, their use can also result in toxic side effects due to their impact on non-target cells.
