How Can We Address These Differences in Toxicological Studies?
To mitigate the challenges posed by species-specific differences, researchers employ several strategies:
Cross-Species Extrapolation: This involves using data from multiple species to predict human responses more accurately. In Vitro and Computational Models:In vitro assays and computational models can simulate human-specific metabolic processes, reducing reliance on animal testing. Genetically Modified Models: Animals are genetically modified to possess human-like metabolic pathways, providing more relevant data for human risk assessment.
