How Do Genetic Variations in SLC Transporters Impact Toxicology?
Genetic polymorphisms in SLC transporters can lead to inter-individual differences in drug response and toxicity. Variants in genes encoding transporters like SLC22A1 (OCT1) and SLC01B1 (OATP1B1) have been associated with altered drug metabolism and increased risk of adverse drug reactions. Understanding these genetic variations helps in predicting patient-specific responses to drugs and toxins, guiding more effective and safer therapeutic strategies.
