Are SLC Transporters Involved in Multidrug Resistance?
Yes, SLC transporters can contribute to multidrug resistance (MDR) in cancer and infectious diseases by affecting the efflux and uptake of therapeutic agents. For instance, SLC transporters like SLC7A11 are known to mediate resistance to certain chemotherapeutic agents. This resistance complicates treatment regimens and necessitates the development of inhibitors or alternative therapies to overcome MDR and improve clinical outcomes.
