Solute carrier (SLC) transporters are a large family of membrane-bound proteins responsible for the transport of a wide variety of substrates across cellular membranes. These substrates can include ions, metabolites, and drugs, playing a crucial role in maintaining cellular homeostasis and influencing the pharmacokinetics and toxicity of various compounds. In toxicology, understanding the function and regulation of SLC transporters is essential for predicting how toxins and therapeutic drugs are absorbed, distributed, metabolized, and excreted by the body.
