What Methods are Used to Study SLC Transporters in Toxicology?
Several methods are employed to study SLC transporters, including in vitro assays using cell lines expressing specific transporters, in vivo studies in genetically modified animal models, and computational modeling. Additionally, techniques such as CRISPR/Cas9 gene editing, RNA interference, and transporter-specific inhibitors are used to dissect the roles of individual transporters in drug and toxin disposition. These studies are crucial for understanding the mechanisms behind drug interactions and toxic responses.
