SLC transporters can influence the toxicity of compounds by modulating their concentration in target tissues. For example, the SLC transporter family member MATE1 is involved in the renal excretion of drugs and toxins. Impaired function of MATE1 can lead to the accumulation of toxic substances in the kidney, contributing to nephrotoxicity. Similarly, defects in the SLC22 family, which includes organic cation and anion transporters, can result in increased susceptibility to drug-induced toxicity.
