SLC transporters significantly impact the absorption, distribution, and excretion of drugs. They are involved in the uptake of drugs into cells and their distribution across different tissues. For instance, transporters like OATP1B1 and OATP1B3 are responsible for the hepatic uptake of statins, impacting their therapeutic and adverse effects. Disruptions in SLC transporter function can lead to altered drug efficacy and increased toxicity, highlighting their importance in personalized medicine.
