How Does Circadian Misalignment Affect Toxicological Responses?
The body's ability to metabolize and respond to toxic substances is closely linked to circadian rhythms. Enzymes responsible for drug metabolism, such as those in the cytochrome P450 family, exhibit circadian variations in their activity levels. Circadian misalignment can therefore alter the pharmacokinetics of drugs, leading to toxicity due to accumulation or reduced efficacy. Additionally, the timing of exposure to toxins can influence the severity of their effects, as the body's defensive mechanisms also follow circadian patterns.
