What are the Clinical Implications of CYP450 Variability?
Understanding CYP450 variability is crucial for personalized medicine. Genetic tests can identify polymorphisms in CYP450 genes, allowing for more accurate dosing of medications. For instance, individuals with poor metabolizer status for CYP2D6 may require lower doses of certain drugs to avoid adverse effects, while those with rapid metabolizer status may need higher doses to achieve therapeutic efficacy.
