What are the interactions of ketoconazole with other drugs?
Ketoconazole is a potent inhibitor of the cytochrome P450 enzyme CYP3A4, which is involved in the metabolism of many drugs. This can lead to significant drug-drug interactions, increasing the risk of toxicity from other medications. For instance, concurrent use of ketoconazole and drugs like cyclosporine, phenytoin, or warfarin can result in elevated blood levels of these drugs, potentially leading to severe adverse effects.
