How does ketoconazole affect the endocrine system?
Ketoconazole can also affect the endocrine system by interfering with steroid synthesis. It inhibits the enzyme cytochrome P450 14α-demethylase, which is involved in the production of various steroids, including cortisol and testosterone. This inhibition can lead to conditions such as hypocortisolism and gynecomastia, especially in patients on long-term or high-dose therapy. Monitoring of hormone levels may be necessary in patients with prolonged exposure to the drug.
