The mechanisms by which toxicants affect ADH are diverse. Ethanol, for instance, acts on the central nervous system to inhibit ADH release. Certain medications, such as carbamazepine and selective serotonin reuptake inhibitors (SSRIs), can stimulate ADH release. Heavy metals and some neurotoxins may interfere with the hypothalamic release of ADH or the renal response to the hormone, exemplifying the complex interplay between toxicants and hormone regulation.
