Autophagy plays a vital role in maintaining neuronal health by degrading dysfunctional proteins and organelles. Dysregulation of autophagy has been implicated in various neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. In the context of neurotoxicity, substances like pesticides and heavy metals can impair autophagic processes, contributing to neuronal damage and disease progression. Enhancing autophagy may offer therapeutic potential in mitigating neurotoxic effects and promoting neuronal survival.